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Electrical Stimulation
​in the eye

1755

LeRoy reports visual sensations generated by applying an electrical current to the eye surface of a blind patient.
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1873

Dor proclaims that electrical stimulation (ES) is effective in the treatment of various eye diseases, based on anecdotal evidence from patients.
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2002

Morimoto shows that directly applying ES to a stump of a severed optic nerve in rats improved the survival of retinal ganglion cells (RGCs).
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2004

Chow carries out study of inactive retinal microchip that only generated ​subthreshold currents from light. Visual improvement in areas far from the chip were induced in patients with retinitis pigmentosa, suggesting that ES induced a general neuroprotective effect.
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2005

Morimoto suggests that one of the mechanisms behind TES induced neuroprotection in rats is the secretion of IGF-1, a neurotrophic factor, from Müller cells.
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2006

Fujikado applies transcorneal electrical stimulation (TES) to patients with nonarteritic anterior optic ischemic neuropathy (NAION) or traumatic optic neuropathy (TON), and notes improvement in visual acuity of most patients.
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2009

Ni applies repeated TES (every 3 days) to Sprague-Dawley rats, and shows it protects against retinal degeneration better than one-time exposure

Tagami compares different protocols (0/2/3/14 times over 14 days) of TES on rats with crushed optic nerve and finds daily stimulation to be the most effective method of promoting RGC survival and optic nerve regeneration.
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2010

Kurimoto shows that TES increases blood flow in eye, which might be a mechanism that protects against ischemic damage (e.g. in NAION).

​2011

​Schatz carries out pilot study of TES on patients with retinitis pigmentosa (RP), which shows enhanced visual field and improved rod cell performance.
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  • Home
  • Technology
    • Vision
    • Validation
    • Development of Electrical Stimulation
    • Targeted Diseases
  • About us
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